Coping with cross-reactive carbohydrate determinants in allergy diagnosis
نویسندگان
چکیده
منابع مشابه
Coping with cross-reactive carbohydrate determinants in allergy diagnosis
A relevant proportion of allergy diagnosis is accomplished by in vitro determination of specific immunglobulin E (sIgE) to extracts from suspected allergens. Such extracts inevitably contain glycoproteins, which may react with patients' IgE. In the case of plant and insect allergens, the relevant epitope structure is an α-1,3-fucose on the Asn-linked sugar residue of so-called N-glycans. Due to...
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BACKGROUND A longstanding debate in allergy is whether or not specific immunoglobulin-E antibodies (sIgE), recognizing cross-reactive carbohydrate determinants (CCD), are able to elicit clinical symptoms. In pollen and food allergy, ≥20% of patients display in-vitro CCD reactivity based on presence of α1,3-fucose and/or β1,2-xylose residues on N-glycans of plant (xylose/fucose) and insect (fuco...
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BACKGROUND Specific IgE antibodies against the low-molecular-weight carbohydrate antigen that does not bridge IgE molecules on mast cells are not associated with clinical symptoms. Cross reactivity can be determined in allergen-specific IgE detection assays when the carbohydrate structures between pollen allergens and plant derived food allergens are similar; in such cases, false positive resul...
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INTRODUCTION The role of cross-reactive carbohydrate determinants (CCDs) in diagnostics of occupational allergy remains unclarified and its clinical relevance is still questioned. The aim of the study was to assess the frequency of positive response to CCDs in the subjects with suspected occupational allergy and the relationship between other diagnostic test results and final diagnosis. MATER...
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Background In food dependent exercise-induced anaphylaxis, a food challenge followed by an exercise test, being the gold standard for diagnosis, might not be feasible under certain circumstances. Therefore, in vitro diagnostic tests can be helpful to clarify severe forms of exercise-related hypersensitivity syndromes. We report two patients with food allergy to non-specific LTPs presenting as e...
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ژورنال
عنوان ژورنال: Allergo Journal International
سال: 2016
ISSN: 2197-0378
DOI: 10.1007/s40629-016-0115-3